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Vol. 55, Issue 3, 614-624, March 1999
Biochemistry and Immunopharmacology Section, Laboratory of
Immunology, National Institute of Allergy and Infectious Diseases,
National Institutes of Health, Bethesda, Maryland (M.K., M.S.); and the
University of Virginia, Charlottesville, Virginia (D.R., N.H.,
J.L.)
Signaling through A2A adenosine receptors
(A2AR) regulates T lymphocyte expansion and modulates T
cell receptor (TCR)-mediated effector functions in vitro. To understand
the role of A2ARs in the regulation of immune response, we
investigated the expression levels of this receptor in different
functional lymphocyte subsets. Monoclonal anti-A2AR
antibody was used to develop a flow cytometric assay to quantify the
expression A2ARs on lymphocytes. We report that detectable
levels of expression of A2ARs are much higher among T cells
than B cells. More CD4+ than CD8+ T cells
express A2ARs, but activation of T cells increases
A2AR expression, predominantly in CD8+ T cells.
No significant differences were found in the proportion of
A2AR+ cells between CD8low and
CD8high T cells or between TCR/CD3low and
TCR/CD3high T cells. Studies of T helper cell subsets
(TH1 and TH2) reveal that lymphokine-producing
cells are much more likely to express A2ARs than are cells
that do not produce lymphokines. These results suggest that
A2ARs are variably expressed on T cell subsets and may
regulate cytokine production in activated T lymphocytes.
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