![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 55, Issue 2, 248-254, February 1999
9 Nicotinic Acetylcholine Receptor Shares Pharmacological
Properties with Type A 
-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors
Instituto de Investigaciones en Ingeniería Genética y
Biología Molecular, In the present study, we provide evidence that the 
9 nicotinic
acetylcholine receptor (nAChR) shares pharmacological properties with
members of the Cys-loop family of receptors. Thus, the type A
-aminobutyric acid receptor antagonist bicuculline, the glycinergic antagonist strychnine, and the type 3 serotonin receptor antagonist ICS-205,930 block ACh-evoked currents in 9-injected Xenopus
laevis oocytes with the following rank order of potency:
strychnine > ICS-205,930 > bicuculline. Block by
antagonists was reflected in an increase in the acetylcholine (ACh)
EC50 value, with no changes in agonist maximal response or
Hill coefficient, which suggests a competitive type of block. Moreover,
whereas neither -aminobutyric acid nor glycine modified ACh-evoked
currents, serotonin blocked responses to ACh in a
concentration-dependent manner. The present results suggest that the
9 nAChR must conserve in its primary structure some residues
responsible for ligand binding common to other Cys-loop receptors. In
addition, it adds further evidence that the 9 nAChR and the
cholinergic receptor present at the base of cochlear outer hair cells
have similar pharmacological properties.
Copyright © 1999 by The American Society for Pharmacology and Experimental Therapeutics
This article has been cited by other articles:
|
|
 |
|
  D. E. Vetter, E. Katz, S. F. Maison, J. Taranda, S. Turcan, J. Ballestero, M. C. Liberman, A. B. Elgoyhen, and J. Boulter The {alpha}10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system PNAS, December 18, 2007; 104(51): 20594 - 20599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fraterman, T. S. Khurana, and N. A. Rubinstein Identification of acetylcholine receptor subunits differentially expressed in singly and multiply innervated fibers of extraocular muscles. Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 3828 - 3834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. V. Plazas, E. Katz, M. E. Gomez-Casati, C. Bouzat, and A. B. Elgoyhen Stoichiometry of the {alpha}9{alpha}10 Nicotinic Cholinergic Receptor J. Neurosci., November 23, 2005; 25(47): 10905 - 10912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Gomez-Casati, P. A Fuchs, A. B. Elgoyhen, and E. Katz Biophysical and pharmacological characterization of nicotinic cholinergic receptors in rat cochlear inner hair cells J. Physiol., July 1, 2005; 566(1): 103 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Rau, R. D. Johnson, and B. Y. Cooper Nicotinic AChR in Subclassified Capsaicin-Sensitive and -Insensitive Nociceptors of the Rat DRG J Neurophysiol, March 1, 2005; 93(3): 1358 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Chernyavsky, J. Arredondo, L. M. Marubio, and S. A. Grando Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes J. Cell Sci., November 1, 2004; 117(23): 5665 - 5679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Libert, J. Bonnefont, E. Bourinet, E. Doucet, A. Alloui, M. Hamon, J. Nargeot, and A. Eschalier Acetaminophen: A Central Analgesic Drug That Involves a Spinal Tropisetron-Sensitive, Non-5-HT3 Receptor-Mediated Effect Mol. Pharmacol., September 1, 2004; 66(3): 728 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Baker, R. Zwart, E. Sher, and N. S. Millar Pharmacological Properties of {alpha}9{alpha}10 Nicotinic Acetylcholine Receptors Revealed by Heterologous Expression of Subunit Chimeras Mol. Pharmacol., February 1, 2004; 65(2): 453 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Rothlin, M. I. Lioudyno, A. F. Silbering, P. V. Plazas, M. E. G. Casati, E. Katz, P. S. Guth, and A. B. Elgoyhen Direct Interaction of Serotonin Type 3 Receptor Ligands with Recombinant and Native alpha 9alpha 10-Containing Nicotinic Cholinergic Receptors Mol. Pharmacol., May 1, 2003; 63(5): 1067 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bray, J.-H. Son, P. Kumar, J. D. Harris, and S. Meizel A Role for the Human Sperm Glycine Receptor/Cl- Channel in the Acrosome Reaction Initiated by Recombinant ZP3 Biol Reprod, January 1, 2002; 66(1): 91 - 97. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Wang, E. F. R. Pereira, A. D. J. Maus, N. S. Ostlie, D. Navaneetham, S. Lei, E. X. Albuquerque, and B. M. Conti-Fine Human Bronchial Epithelial and Endothelial Cells Express alpha 7 Nicotinic Acetylcholine Receptors Mol. Pharmacol., December 1, 2001; 60(6): 1201 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fujino and D. Oertel Cholinergic Modulation of Stellate Cells in the Mammalian Ventral Cochlear Nucleus J. Neurosci., September 15, 2001; 21(18): 7372 - 7383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Elgoyhen, D. E. Vetter, E. Katz, C. V. Rothlin, S. F. Heinemann, and J. Boulter alpha 10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells PNAS, March 1, 2001; (2001) 51622798. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. T. Nguyen, A. Ndoye, and S. A. Grando Novel Human {alpha}9 Acetylcholine Receptor Regulating Keratinocyte Adhesion is Targeted by Pemphigus Vulgaris Autoimmunity Am. J. Pathol., October 1, 2000; 157(4): 1377 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zuo, J. Treadaway, T. W. Buckner, and B. Fritzsch Visualization of alpha 9 acetylcholine receptor expression in hair cells of transgenic mice containing a modified bacterial artificial chromosome PNAS, November 23, 1999; 96(24): 14100 - 14105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Palma, S. Fucile, B. Barabino, R. Miledi, and F. Eusebi Strychnine activates neuronal alpha 7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains PNAS, November 9, 1999; 96(23): 13421 - 13426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Elgoyhen, D. E. Vetter, E. Katz, C. V. Rothlin, S. F. Heinemann, and J. Boulter alpha 10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells PNAS, March 13, 2001; 98(6): 3501 - 3506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka, K. Nagashima, R. M. McAllen, and K. Kanosue Role of the medullary raphe in thermoregulatory vasomotor control in rats J. Physiol., April 15, 2002; 540(2): 657 - 664. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
