![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 54, Issue 3, 463-473, September 1998
Chemical Industry Institute of Toxicology, Research Triangle Park,
North Carolina 27709 (J.C.C., L.-Q.F., S.B., S.P.A., R.C.C.), and
Department of Medical Nutrition, Huddinge University Hospital, Novum
S-141 86, Huddinge, Sweden (J.C.C., C.B., A.M., J.-A.G.)
In this study, we show that peroxisome proliferator chemical (PPC)
exposure leads to alterations in the expression of genes in rat liver
regulated by the sex-specific growth hormone secretory pattern and
induced during inflammation. Expression of the male-specific cytochrome P450 (P450) 2C11 and 
2 urinary
globulin (2u) genes and the female-specific
P450 2C12 gene was down-regulated by some PPC. Expression of
P450 2C13, also under control by the sex-specific growth
hormone secretory pattern, was not altered by PPC treatment, indicating
that regulation of CYP2C family members does not involve perturbation of the growth hormone secretory pattern. In contrast to
the increases in expression observed when inflammation was induced in
male rats, two positive acute-phase response genes, 1-acid glycoprotein and 
-fibrinogen, were decreased
by PPC exposure. The down-regulation of the P450 2C11 by
WY-14,643 could be reproduced in cultured rat hepatocytes, indicating
the down-regulation is a direct effect. Experiments in wild-type mice
and mice that lacked a functional peroxisome
proliferator-activated receptor- gene showed that
down-regulation by WY of 1-acid glycoprotein,
-fibrinogen, and a mouse homologue of 2u
was dependent on peroxisome proliferator-activated receptor- expression. Our results demonstrate that PPC exposure leads to down-regulation of diverse liver-specific genes, including CYP2C family members important in hormonal homeostasis and
acute-phase response genes important in inflammatory responses.
This article has been cited by other articles:
|
|
 |
|
  M. B. Rosen, B. D. Abbott, D. C. Wolf, J. C. Corton, C. R. Wood, J. E. Schmid, K. P. Das, R. D. Zehr, E. T. Blair, and C. Lau Gene Profiling in the Livers of Wild-type and PPAR{alpha}-Null Mice Exposed to Perfluorooctanoic Acid Toxicol Pathol, June 1, 2008; 36(4): 592 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Y. Ng, Y. Huang, L. M. Reddy, J. R. Falck, E. T. Lin, and D. L. Kroetz Cytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor {alpha} Drug Metab. Dispos., July 1, 2007; 35(7): 1126 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pozzi, M. R. Ibanez, A. E. Gatica, S. Yang, S. Wei, S. Mei, J. R. Falck, and J. H. Capdevila Peroxisomal Proliferator-activated Receptor-{alpha}-dependent Inhibition of Endothelial Cell Proliferation and Tumorigenesis J. Biol. Chem., June 15, 2007; 282(24): 17685 - 17695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gatica, M. C. Aguilera, D. Contador, G. Loyola, C. O. Pinto, L. Amigo, J. E. Tichauer, S. Zanlungo, and M. Bronfman P450 CYP2C epoxygenase and CYP4A {omega}-hydroxylase mediate ciprofibrate-induced PPAR{alpha}-dependent peroxisomal proliferation J. Lipid Res., April 1, 2007; 48(4): 924 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Spector and A. W. Norris Action of epoxyeicosatrienoic acids on cellular function Am J Physiol Cell Physiol, March 1, 2007; 292(3): C996 - C1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Bilby, T. Jenkins, C. R. Staples, and W. W. Thatcher Pregnancy, Bovine Somatotropin, and Dietary n-3 Fatty Acids in Lactating Dairy Cows: III. Fatty Acid Distribution. J Dairy Sci, September 1, 2006; 89(9): 3386 - 3399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Xiao, S. P. Anderson, C. Swanson, R. Bahnemann, K. A. Voss, A. J. Stauber, and J. C. Corton Activation of Peroxisome Proliferator-Activated Receptor Alpha Enhances Apoptosis in the Mouse Liver Toxicol. Sci., August 1, 2006; 92(2): 368 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Currie, V. Bombail, J. D. Oliver, D. J. Moore, F. L. Lim, V. Gwilliam, I. Kimber, K. Chipman, J. G. Moggs, and G. Orphanides Gene Ontology Mapping as an Unbiased Method for Identifying Molecular Pathways and Processes Affected by Toxicant Exposure: Application to Acute Effects Caused by the Rodent Non-Genotoxic Carcinogen Diethylhexylphthalate Toxicol. Sci., August 1, 2005; 86(2): 453 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mouthiers, A. Baillet, C. Delomenie, D. Porquet, and N. Mejdoubi-Charef Peroxisome Proliferator-Activated Receptor {alpha} Physically Interacts with CCAAT/Enhancer Binding Protein (C/EBP{beta}) to Inhibit C/EBP{beta}-Responsive {alpha}1-Acid Glycoprotein Gene Expression Mol. Endocrinol., May 1, 2005; 19(5): 1135 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Stauber, H. Brown-Borg, J. Liu, M. P. Waalkes, A. Laughter, R. A. Staben, J. C. Coley, C. Swanson, K. A. Voss, J. J. Kopchick, et al. Constitutive Expression of Peroxisome Proliferator-Activated Receptor {alpha}-Regulated Genes in Dwarf Mice Mol. Pharmacol., March 1, 2005; 67(3): 681 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Corton and P. J. Lapinskas Peroxisome Proliferator-Activated Receptors: Mediators of Phthalate Ester-Induced Effects in the Male Reproductive Tract? Toxicol. Sci., January 1, 2005; 83(1): 4 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Howroyd, C. Swanson, C. Dunn, R. C. Cattley, and J. C. Corton Decreased Longevity and Enhancement of Age-Dependent Lesions in Mice Lacking the Nuclear Receptor Peroxisome Proliferator-Activated Receptor {alpha} (PPAR{alpha}) Toxicol Pathol, August 1, 2004; 32(5): 591 - 599. [Abstract] [PDF]
|
|
|
|
|
|
C. Blanquart, R. Mansouri, R. Paumelle, J.-C. Fruchart, B. Staels, and C. Glineur The Protein Kinase C Signaling Pathway Regulates a Molecular Switch between Transactivation and Transrepression Activity of the Peroxisome Proliferator-Activated Receptor {alpha} Mol. Endocrinol., August 1, 2004; 18(8): 1906 - 1918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Riddick, C. Lee, A. Bhathena, Y. E. Timsit, P.-Y. Cheng, E. T. Morgan, R. A. Prough, S. L. Ripp, K. K. M. Miller, A. Jahan, et al. TRANSCRIPTIONAL SUPPRESSION OF CYTOCHROME P450 GENES BY ENDOGENOUS AND EXOGENOUS CHEMICALS Drug Metab. Dispos., April 1, 2004; 32(4): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yadetie, A. Laegreid, I. Bakke, W. Kusnierczyk, J. Komorowski, H. L. Waldum, and A. K. Sandvik Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-{alpha} agonist ciprofibrate Physiol Genomics, September 29, 2003; 15(1): 9 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Shipley and D. J. Waxman Down-Regulation of STAT5b Transcriptional Activity by Ligand-Activated Peroxisome Proliferator-Activated Receptor (PPAR) {alpha} and PPAR{gamma} Mol. Pharmacol., August 1, 2003; 64(2): 355 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Ripp, K. C. Falkner, M. L. Pendleton, V. Tamasi, and R. A. Prough Regulation of CYP2C11 by Dehydroepiandrosterone and Peroxisome Proliferators: Identification of the Negative Regulatory Region of the Gene Mol. Pharmacol., July 1, 2003; 64(1): 113 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Cowart, S. Wei, M.-H. Hsu, E. F. Johnson, M. U. Krishna, J. R. Falck, and J. H. Capdevila The CYP4A Isoforms Hydroxylate Epoxyeicosatrienoic Acids to Form High Affinity Peroxisome Proliferator-activated Receptor Ligands J. Biol. Chem., September 13, 2002; 277(38): 35105 - 35112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Pass, W. Becker, R. Kluge, K. Linnartz, L. Plum, K. Giesen, and H.-G. Joost Effect of Hyperinsulinemia and Type 2 Diabetes-Like Hyperglycemia on Expression of Hepatic Cytochrome P450 and Glutathione S-Transferase Isoforms in a New Zealand Obese-Derived Mouse Backcross Population J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 442 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Anderson, C. S. Dunn, R. C. Cattley, and J.C. Corton Hepatocellular proliferation in response to a peroxisome proliferator does not require TNF{alpha} signaling Carcinogenesis, November 1, 2001; 22(11): 1843 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Akiyama, C. J. Nicol, C. Fievet, B. Staels, J. M. Ward, J. Auwerx, S. S. T. Lee, F. J. Gonzalez, and J. M. Peters Peroxisome Proliferator-activated Receptor-alpha Regulates Lipid Homeostasis, but Is Not Associated with Obesity. STUDIES WITH CONGENIC MOUSE LINES J. Biol. Chem., October 12, 2001; 276(42): 39088 - 39093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. KERSTEN, S. MANDARD, P. ESCHER, F. J. GONZALEZ, S. TAFURI, B. DESVERGNE, and W. WAHLI The peroxisome proliferator-activated receptor {alpha} regulates amino acid metabolism FASEB J, September 1, 2001; 15(11): 1971 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Borghoff, J. S. Prescott, D. B. Janszen, B. A. Wong, and J. I. Everitt {{alpha}}2u-Globulin Nephropathy, Renal Cell Proliferation, and Dosimetry of Inhaled tert-Butyl Alcohol in Male and Female F-344 Rats Toxicol. Sci., May 1, 2001; 61(1): 176 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Cui, H. Kawashima, T. B. Barclay, J. M. Peters, F. J. Gonzalez, E. T. Morgan, and H. W. Strobel Molecular Cloning and Regulation of Expression of Two Novel Mouse CYP4F Genes: Expression in Peroxisome Proliferator-Activated Receptor alpha -Deficient Mice upon Lipopolysaccharide and Clofibrate Challenges J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 542 - 550. [Abstract] [Full Text]
|
|
|
|
|
|
E. T. Morgan Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How? Drug Metab. Dispos., March 1, 2001; 29(3): 207 - 212. [Abstract] [Full Text]
|
|
|
|
|
|
G. M. Su, R. M. Sefton, and M. Murray Down-Regulation of Rat Hepatic Microsomal Cytochromes P-450 in Microvesicular Steatosis Induced by Orotic Acid J. Pharmacol. Exp. Ther., December 1, 1999; 291(3): 953 - 959. [Abstract] [Full Text]
|
|
|
|
|
|
T. B. Barclay, J. M. Peters, M. B. Sewer, L. Ferrari, F. J. Gonzalez, and E. T. Morgan Modulation of Cytochrome P-450 Gene Expression in Endotoxemic Mice Is Tissue Specific and Peroxisome Proliferator-Activated Receptor-alpha Dependent J. Pharmacol. Exp. Ther., September 1, 1999; 290(3): 1250 - 1257. [Abstract] [Full Text]
|
|
|
|
|
|
P. Gervois, N. Vu-Dac, R. Kleemann, M. Kockx, G. Dubois, B. Laine, V. Kosykh, J.-C. Fruchart, T. Kooistra, and B. Staels Negative Regulation of Human Fibrinogen Gene Expression by Peroxisome Proliferator-activated Receptor alpha Agonists via Inhibition of CCAAT Box/Enhancer-binding Protein beta J. Biol. Chem., August 31, 2001; 276(36): 33471 - 33477. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
