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Vol. 54, Issue 2, 372-378, August 1998
Department of Pharmacology, School of Medical Sciences, University
of Bristol, Bristol BS8 1TD, UK
ATP-gated cation channels (P2X receptors) exist on the soma of
proprioceptive neurons in the trigeminal mesencephalic nucleus (MNV) in
the brain stem. However, these pseudomonopolar neurons seem to receive
no synaptic input to their soma; we therefore hypothesized that in MNV
neurons, the P2X receptors of importance may be those located on their
central terminal projections. Here, we show in trigeminal mesencephalic
motor nucleus neurons, which receive their major input from the MNV,
that both exogenous ATP (1 mM) and high frequency focal
stimulation to evoke endogenous ATP release enhanced the frequency of
spontaneous fast excitatory postsynaptic currents (EPSCs) with no
change in their amplitude. The enhancement was reduced by the
antagonists suramin (300 µM) and
pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid (30 µM) and persisted when action potential conduction was
blocked with tetrodotoxin (1 µM). Thus, functional P2X
receptors are expressed on nerve terminals in the brain stem, where
they increase the spontaneous release of glutamate onto trigeminal
mesencephalic motor nucleus neurons.
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