![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 52, Issue 6, 928-934, 1997
Department of Pharmacology, University of North Carolina School of
Medicine, Chapel Hill, North Carolina 27599
A family of G protein-coupled P2Y receptors that are activated by
adenine and uridine nucleotides has been identified recently. Degenerate primers based on conserved sequences in these P2Y receptors were used to amplify turkey DNA, which was used to isolate the complete
coding sequence of a cDNA that encodes a novel G protein-coupled receptor. Stable expression of this avian cDNA in 1321N1 human astrocytoma cells resulted in the conveyance of marked inositol phosphate responses to various nucleotides. Although this cloned avian
receptor exhibited its highest homology to the previously cloned
mammalian P2Y4 receptor, its pharmacological selectivity was not consistent with the avian receptor's being a species homologue of the P2Y4 receptor. That is, whereas the P2Y4
receptor is selectively activated by UTP and is not activated by ATP or
AP4A, the novel avian receptor was potently activated by
ATP and AP4A as well as by UTP. Taken together, these
results describe the identification of an avian phospholipase C-coupled
P2Y receptor that, like the mammalian P2Y2 receptor, is
activated by both adenine and uridine nucleotides.
This article has been cited by other articles:
|
|
 |
|
  J. Mateo, S. Kreda, C. E. Henry, T. K. Harden, and J. L. Boyer Requirement of Cys399 for Processing of the Human Ecto-ATPase (NTPDase2) and Its Implications for Determination of the Activities of Splice Variants of the Enzyme J. Biol. Chem., October 10, 2003; 278(41): 39960 - 39968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Kulkarni, M. D. Trousdale, D. Stevenson, H. J. Gukasyan, M. H. I. Shiue, K.-J. Kim, R. W. Read, and V. H. L. Lee Nucleotide-Induced Restoration of Conjunctival Chloride and Fluid Secretion in Adenovirus Type 5-Infected Pigmented Rabbit Eyes J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 1206 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sak, J.-M. Boeynaems, and H. Everaus Involvement of P2Y receptors in the differentiation of haematopoietic cells J. Leukoc. Biol., April 1, 2003; 73(4): 442 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Alvarado-Castillo, P. Lozano-Zarain, J. Mateo, T. K. Harden, and J. L. Boyer A Fusion Protein of the Human P2Y1 Receptor and NTPDase1 Exhibits Functional Activities of the Native Receptor and Ectoenzyme and Reduced Signaling Responses to Endogenously Released Nucleotides Mol. Pharmacol., September 1, 2002; 62(3): 521 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kennedy, A.-D. Qi, C. L. Herold, T. K. Harden, and R. A. Nicholas ATP, an Agonist at the Rat P2Y4 Receptor, Is an Antagonist at the Human P2Y4 Receptor Mol. Pharmacol., May 1, 2000; 57(5): 926 - 931. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Short, J. L. Boyer, and R. L. Juliano Integrins Regulate the Linkage between Upstream and Downstream Events in G Protein-coupled Receptor Signaling to Mitogen-activated Protein Kinase J. Biol. Chem., April 21, 2000; 275(17): 12970 - 12977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Boyer, S. M. Delaney, D. Villanueva, and T. K. Harden A Molecularly Identified P2Y Receptor Simultaneously Activates Phospholipase C and Inhibits Adenylyl Cyclase and Is Nonselectively Activated by All Nucleoside Triphosphates Mol. Pharmacol., April 1, 2000; 57(4): 805 - 810. [Abstract] [Full Text]
|
|
|
|
|
|
K.-I. Hosoya, H. Ueda, K.-J. Kim, and V. H. L. Lee Nucleotide Stimulation of Cl- Secretion in the Pigmented Rabbit Conjunctiva J. Pharmacol. Exp. Ther., October 1, 1999; 291(1): 53 - 59. [Abstract] [Full Text]
|
|
|
|
|
|
Q. Li, M. Olesky, R. K. Palmer, T. K. Harden, and R. A. Nicholas Evidence that the p2y3 Receptor Is the Avian Homologue of the Mammalian P2Y6 Receptor Mol. Pharmacol., September 1, 1998; 54(3): 541 - 546. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Dranoff, A. F. O'Neill, A. M. Franco, S.-Y. Cai, G. C. Connolly, N. Ballatori, J. L. Boyer, and M. H. Nathanson A Primitive ATP Receptor from the Little Skate Raja erinacea J. Biol. Chem., September 22, 2000; 275(39): 30701 - 30706. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
