![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Molecular Pharmacology, Volume 52, Issue 5, 755-763
Departments of Biological Chemistry and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Store-operated Ca2+ entry, a mode of Ca2+ influx activated by depletion of Ca2+ from the internal stores, has been detected in a wide variety of cell types and may be the primary mechanism for Ca2+ entry in nonexcitable cells. Nevertheless, until recently, no candidate store-operated channel (SOC) had been identified molecularly. Through the serendipity of Drosophila genetics, a candidate SOC, referred to as Transient Receptor Potential (TRP), has been identified that is essential for the light-induced cation conductance in photoreceptor cells. A combination of in vitro and in vivo studies has provided strong evidence that TRP is a bona fide SOC. Moreover, TRP forms a supramolecular complex, proposed to be critical for feedback regulation and/or activation, that includes rhodopsin, phospholipase C, protein kinase C, calmodulin, and the PDZ domain-containing protein, INAD. INAD seems to be a scaffolding protein that links TRP with several of these other proteins in the complex. TRP also complexes with a related channel subunit, TRP-like, to form a heteromultimer with conductance characteristics distinct from those of TRP or TRP-like homomultimers. A family of proteins related to TRP is conserved from Caenorhabditis elegans to humans, and recent evidence indicates that at least some of these proteins are SOCs. The human TRP-related proteins may mediate many of the store-operated conductances that have been identified previously in a plethora of human cells.
This article has been cited by other articles:
|
|
 |
|
  C. S. Facemire and W. J. Arendshorst Calmodulin mediates norepinephrine-induced receptor-operated calcium entry in preglomerular resistance arteries Am J Physiol Renal Physiol, July 1, 2005; 289(1): F127 - F136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Laporte, A. Hui, and I. Laher Pharmacological Modulation of Sarcoplasmic Reticulum Function in Smooth Muscle Pharmacol. Rev., December 1, 2004; 56(4): 439 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Lievremont, G. St. J. Bird, and J. W. Putney Jr. Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1709 - C1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Erler, D. Hirnet, U. Wissenbach, V. Flockerzi, and B. A. Niemeyer Ca2+-selective Transient Receptor Potential V Channel Architecture and Function Require a Specific Ankyrin Repeat J. Biol. Chem., August 13, 2004; 279(33): 34456 - 34463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-B. Huang, A. L. Kindzelskii, A. J. Clark, and H. R. Petty Identification of Channels Promoting Calcium Spikes and Waves in HT1080 Tumor Cells: Their Apparent Roles in Cell Motility and Invasion Cancer Res., April 1, 2004; 64(7): 2482 - 2489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ma, D. Rundle, J. Jacks, M. Koch, T. Downs, and L. Tsiokas Inhibitor of Myogenic Family, a Novel Suppressor of Store-operated Currents through an Interaction with TRPC1 J. Biol. Chem., December 26, 2003; 278(52): 52763 - 52772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vanden Abeele, M. Roudbaraki, Y. Shuba, R. Skryma, and N. Prevarskaya Store-operated Ca2+ Current in Prostate Cancer Epithelial Cells. ROLE OF ENDOGENOUS Ca2+ TRANSPORTER TYPE 1 J. Biol. Chem., April 18, 2003; 278(17): 15381 - 15389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Su, D. S. Barker, P. Csutora, T. Chang, R. L. Shoemaker, R. B. Marchase, and J. E. Blalock Regulation of Ca2+ release-activated Ca2+ channels by INAD and Ca2+ influx factor Am J Physiol Cell Physiol, February 1, 2003; 284(2): C497 - C505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, J.-S. Bian, A. Kagan, and T. V. McDonald CaT1 Contributes to the Stores-operated Calcium Current in Jurkat T-lymphocytes J. Biol. Chem., November 27, 2002; 277(49): 47175 - 47183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Hong, S. Park, C. Geng, K. Baek, J. D. Bowman, J. Yoon, and W. L. Pak Single Amino Acid Change in the Fifth Transmembrane Segment of the TRP Ca2+ Channel Causes Massive Degeneration of Photoreceptors J. Biol. Chem., September 6, 2002; 277(37): 33884 - 33889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yang, A. Gupta, S. G. Shlykov, R. Corrigan, S. Tsujimoto, and B. M. Sanborn Multiple Trp Isoforms Implicated in Capacitative Calcium Entry Are Expressed in Human Pregnant Myometrium and Myometrial Cells Biol Reprod, September 1, 2002; 67(3): 988 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Minke and B. Cook TRP Channel Proteins and Signal Transduction Physiol Rev, April 1, 2002; 82(2): 429 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Riccio, C. Mattei, R. E. Kelsell, A. D. Medhurst, A. R. Calver, A. D. Randall, J. B. Davis, C. D. Benham, and M. N. Pangalos Cloning and Functional Expression of Human Short TRP7, a Candidate Protein for Store-operated Ca2+ Influx J. Biol. Chem., March 29, 2002; 277(14): 12302 - 12309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tsavaler, M. H. Shapero, S. Morkowski, and R. Laus Trp-p8, a Novel Prostate-specific Gene, Is Up-Regulated in Prostate Cancer and Other Malignancies and Shares High Homology with Transient Receptor Potential Calcium Channel Proteins Cancer Res., May 1, 2001; 61(9): 3760 - 3769. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. A. Niemeyer, C. Bergs, U. Wissenbach, V. Flockerzi, and C. Trost Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin PNAS, March 13, 2001; 98(6): 3600 - 3605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Kishigami, T Ogasawara, Y Watanabe, M Hirata, T Maeda, F Hayashi, and Y Tsukahara Inositol-1,4,5-trisphosphate-binding proteins controlling the phototransduction cascade of invertebrate visual cells J. Exp. Biol., January 2, 2001; 204(3): 487 - 493. [Abstract] [PDF]
|
|
|
|
 |
|
 R. MA and S. C. SANSOM Epidermal Growth Factor Activates Store-Operated Calcium Channels in Human Glomerular Mesangial Cells J. Am. Soc. Nephrol., January 1, 2001; 12(1): 47 - 53. [Abstract] [Full Text]
|
|
|
|
|
|
A. Kuruma, Y. Hirayama, and H. C. Hartzell A hyperpolarization- and acid-activated nonselective cation current in Xenopus oocytes Am J Physiol Cell Physiol, November 1, 2000; 279(5): C1401 - C1413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Beaudet, R. L. Parsons, K. M. Braas, and V. May Mechanisms Mediating Pituitary Adenylate Cyclase-Activating Polypeptide Depolarization of Rat Sympathetic Neurons J. Neurosci., October 1, 2000; 20(19): 7353 - 7361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Agam, M. von Campenhausen, S. Levy, H. C. Ben-Ami, B. Cook, K. Kirschfeld, and B. Minke Metabolic Stress Reversibly Activates the Drosophila Light-Sensitive Channels TRP and TRPL In Vivo J. Neurosci., August 1, 2000; 20(15): 5748 - 5755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Lockwich, X. Liu, B. B. Singh, J. Jadlowiec, S. Weiland, and I. S. Ambudkar Assembly of Trp1 in a Signaling Complex Associated with Caveolin-Scaffolding Lipid Raft Domains J. Biol. Chem., April 14, 2000; 275(16): 11934 - 11942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Kwon, C. S. Park, K.-r. Choi, C.-S. Park, J. Ahnn, J. I. Kim, S. H. Eom, S. J. Kaufman, and W. K. Song Calreticulin Couples Calcium Release and Calcium Influx in Integrin-mediated Calcium Signaling Mol. Biol. Cell, April 1, 2000; 11(4): 1433 - 1443. [Abstract] [Full Text]
|
|
|
|
|
|
J. Yoon, H. C. Ben-Ami, Y. S. Hong, S. Park, L. L. R. Strong, J. Bowman, C. Geng, K. Baek, B. Minke, and W. L. Pak Novel Mechanism of Massive Photoreceptor Degeneration Caused by Mutations in the trp Gene of Drosophila J. Neurosci., January 15, 2000; 20(2): 649 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Li, C. Geng, H.-T. Leung, Y. S. Hong, L. L. R. Strong, S. Schneuwly, and W. L. Pak INAF, a protein required for transient receptor potential Ca2+ channel function PNAS, November 9, 1999; 96(23): 13474 - 13479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Taupenot, M. Mahata, S. K. Mahata, and D. T. O’Connor Time-Dependent Effects of the Neuropeptide PACAP on Catecholamine Secretion : Stimulation and Desensitization Hypertension, November 1, 1999; 34(5): 1152 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Balzer, B. Lintschinger, and K. Groschner Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells Cardiovasc Res, May 1, 1999; 42(2): 543 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, B. O'Connell, R. Dykeman, T. Sakai, C. Delporte, W. Swaim, X. Zhu, L. Birnbaumer, and I. S. Ambudkar Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein Am J Physiol Cell Physiol, April 1, 1999; 276(4): C969 - C979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tsiokas, T. Arnould, C. Zhu, E. Kim, G. Walz, and V. P. Sukhatme Specific association of the gene product of PKD2 with the TRPC1 channel PNAS, March 30, 1999; 96(7): 3934 - 3939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jaquemar, T. Schenker, and B. Trueb An Ankyrin-like Protein with Transmembrane Domains Is Specifically Lost after Oncogenic Transformation of Human Fibroblasts J. Biol. Chem., March 12, 1999; 274(11): 7325 - 7333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vazquez, A. R. de Boland, and R. L. Boland 1alpha ,25-Dihydroxy-vitamin-D3-induced Store-operated Ca2+ Influx in Skeletal Muscle Cells. MODULATION BY PHOSPHOLIPASE C, PROTEIN KINASE C, AND TYROSINE KINASES J. Biol. Chem., December 18, 1998; 273(51): 33954 - 33960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Z. S. Xu, P. D. Wes, H. Chen, H.-S. Li, M. Yu, S. Morgan, Y. Liu, and C. Montell Retinal Targets for Calmodulin Include Proteins Implicated in Synaptic Transmission J. Biol. Chem., November 20, 1998; 273(47): 31297 - 31307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-Z. S. Xu, A. Choudhury, X. Li, and C. Montell Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins J. Cell Biol., July 27, 1998; 142(2): 545 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vazquez, A. R. de Boland, and R. L. Boland Involvement of Calmodulin in 1alpha ,25-Dihydroxyvitamin D3 Stimulation of Store-operated Ca2+ Influx in Skeletal Muscle Cells J. Biol. Chem., May 19, 2000; 275(21): 16134 - 16138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Trepakova, P. Csutora, D. L. Hunton, R. B. Marchase, R. A. Cohen, and V. M. Bolotina Calcium Influx Factor Directly Activates Store-operated Cation Channels in Vascular Smooth Muscle Cells J. Biol. Chem., August 18, 2000; 275(34): 26158 - 26163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Trepakova, M. Gericke, Y. Hirakawa, R. M. Weisbrod, R. A. Cohen, and V. M. Bolotina Properties of a Native Cation Channel Activated by Ca2+ Store Depletion in Vascular Smooth Muscle Cells J. Biol. Chem., March 9, 2001; 276(11): 7782 - 7790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ma, J. Pluznick, P. Kudlacek, and S. C. Sansom Protein Kinase C Activates Store-operated Ca2+ Channels in Human Glomerular Mesangial Cells J. Biol. Chem., July 6, 2001; 276(28): 25759 - 25765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Mengerink, G. W. Moy, and V. D. Vacquier suREJ3, a Polycystin-1 Protein, Is Cleaved at the GPS Domain and Localizes to the Acrosomal Region of Sea Urchin Sperm J. Biol. Chem., January 4, 2002; 277(2): 943 - 948. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
